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Notably, ultraviolet light-induced pyrimidine dimers are repaired primarily via the NER, whereas radiation-induced DSBs are processed by either HR or NHEJ (50), with distinct spatiotemporal specificities: HR utilizes sister chromatids for DSB repair exclusively in the S/G2 phase, whereas NHEJ directly ligates breaks throughout the cell cycle (11,51) (Fig

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Amsterdam, The Netherlands: 2010